•In the 16th century, the size and power of the Ottoman Empire reached its peak. Since the conquest of Istanbul by Sultan Mehmet the Conqueror in 1453, the Ottomans had engaged in active expansion, both in land and on the sea. Seeking the legitimization and prestige associated with guarding the Islamic Holy Cities of Mecca and Medina.
•The Ottomans marched southward and eastward towards Arabia and Persia. But the conquest of Istanbul had opened the door to Europe, so the Ottomans also advanced westwards towards the Balkans. With the establishment of its Navy in the late 1400s, the Ottomans soon came in conflict with the seafaring Italian city states.
•By the beginning of the 1500s, however, the Ottomans had emerged as the dominant power in the Eastern Mediterranean. These successes in turn paved the way for Ottoman seamen to enter the Red Sea and Indian Ocean, thereby threatening the European trade routes to the East, and bringing the Ottomans into conflict with the Portuguese and Spain.